Blar i forfatter "Ragazzi, Lorenzo"

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    • Anxiolytic-like Effects of the Positive GABA-B Receptor Modulator GS39783 Correlate with Mice's Individual Basal Anxiety and Stress Reactivity 

      Bicakci, Ahmet Oguzhan; Sarkar, Mousumi; Chang, Yu-Hsin; Kahl, Evelyn; Ragazzi, Lorenzo; Moldes-Anaya, Angel; Fendt, Markus (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-16)
      Positive gamma-aminobutyric acid type B (GABAB) receptor modulators such as GS39783 have showed anxiolytic-like effects in several studies while such effects were absent in other studies. These conflicting findings led us hypothesize that the anxiolytic-like effects of such compounds depend on the individual basal anxiety and/or the anxiogenic properties of the used tests. The present study ...

    • Anxiolytic‐like Effects of the Positive GABAB Receptor Modulator GS39783 Correlate with Mice’s Individual Basal Anxiety and Stress Reactivity 

      Bicakci, Ahmet Oguzhan; Sarkar, Mousumi; Chang, Yu-Hsin; Kahl, Evelyn; Ragazzi, Lorenzo; Moldes-Anaya, Angel; Fendt, Markus (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-16)
      Positive gamma-aminobutyric acid type B (GABAB) receptor modulators such as GS39783 have showed anxiolytic-like effects in several studies while such effects were absent in other studies. These conflicting findings led us hypothesize that the anxiolytic-like effects of such compounds depend on the individual basal anxiety and/or the anxiogenic properties of the used tests. The present study ...

    • Efflux of neurotransmitter from brain slices during O2 deprivation – comparing diving and non-diving species 

      Ragazzi, Lorenzo (Master thesis; Mastergradsoppgave, 2014-08-15)
      During hypoxic insult, neuronal tissue undergoes an excitotoxic cascade of events leading to cell death. This response involves loss of membrane potential and uncontrolled release of primarily excitatory neurotransmitters. I propose that this fatal cascade is significantly delayed or attenuated in diving species, which are adapted to repeated exposures to hypoxic conditions as a consequence of ...

    • Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons 

      Berntsen, Hanne Friis; Moldes-Anaya, Angel; Bjørklund, Cesilie Granum; Ragazzi, Lorenzo; Haug, Trude M; Strandabø, Rønnaug; Verhaegen, Steven; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Tasker, Andrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-04)
      Perfluoroalkyl acids (PFAAs) are persistent man-made chemicals, ubiquitous in nature and present in human samples. Although restrictions are being introduced, they are still used in industrial processes as well as in consumer products. PFAAs cross the blood-brain-barrier and have been observed to induce adverse neurobehavioural effects in humans and animals as well as adverse effects in neuronal in ...